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Transition-metal-catalyzed enantioselective C-N cross-coupling
Jia Feng1, Long-Long Xi1, Chuan-Jun Lu1
1College of Chemistry and Chemical Engineering, Qingdao University, Ningxia Road 308#, Qingdao 266071, China. renrongliu@qdu.edu.cn.
Chemical Society Reviews
|August 22, 2024
Summary
Chiral amines are vital building blocks. Transition-metal-catalyzed enantioselective C-N cross-coupling offers an efficient synthesis route for diverse chiral amines with high enantioselectivity.
Area of Science:
- Organic Chemistry
- Asymmetric Synthesis
Background:
- Chiral amine scaffolds are crucial in pharmaceuticals, natural products, and materials.
- Efficient synthesis of chiral amines is a key challenge in organic chemistry.
Purpose of the Study:
- To review established protocols for transition-metal-catalyzed enantioselective C-N cross-coupling.
- To provide an outlook on promising future developments in this field.
Main Methods:
- This review consolidates information on enantioselective C-N cross-coupling reactions.
- Key methods discussed include Buchwald-Hartwig, Ullmann-type, and Chan-Evans-Lam reactions.
- Integration of aryliodonium salt and radical chemistry is highlighted.
Main Results:
- Transition-metal-catalyzed enantioselective C-N cross-coupling provides an efficient pathway to chiral amines.
- This approach allows for the synthesis of structurally diverse chiral amines.
- High enantioselectivity is achievable through these methods.
Conclusions:
- Enantioselective C-N cross-coupling is a powerful tool for synthesizing chiral amines.
- The reviewed methods offer attractive routes to valuable chiral amine building blocks.
- Future research holds promise for further advancements in this area.
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