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Related Experiment Video

Updated: May 10, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Association between post-stroke depression and functional outcomes: A systematic review.

Nipaporn Butsing¹, Jaclene A Zauszniewski², Suebsarn Ruksakulpiwat³

¹Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

|August 22, 2024

Summary

Post-stroke depression (PSD) is common and linked to poor functional recovery after stroke. Early assessment and management of PSD are crucial for improving patient outcomes.

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Last Updated: May 10, 2026

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Area of Science:

Neurology
Psychiatry
Rehabilitation Medicine

Background:

Post-stroke depression (PSD) is a significant complication affecting stroke patient recovery.
Existing research on the link between PSD and functional outcomes remains inconsistent.

Purpose of the Study:

To systematically review the prevalence of PSD.
To investigate the association between PSD and functional outcomes in stroke survivors.

Main Methods:

Systematic review of non-experimental studies (cohort, cross-sectional, case-control).
Searched PubMed, MEDLINE, Web of Science, CINAHL Plus until January 2024.
Screened literature using PRISMA guidelines and appraised using Joanna Briggs Institute criteria.

Main Results:

PSD prevalence varied: 12.2%-32.2% (2 weeks), 17.9%-35.5% (1 month), 10.4%-32.0% (3 months).
Significant negative associations found between PSD and functional outcomes (dependence, ADLs, IADLs, physical/cognitive function) from 1 month to 5 years post-stroke.
Depression treatment positively impacted functional outcomes.

Conclusions:

High PSD prevalence observed in the initial three months post-stroke.
PSD is strongly linked to diminished functional outcomes.
Regular PSD assessment and management are vital for optimal stroke recovery.