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Observational study of intracranial compliance analysis in neurologically healthy pediatric patients using a
Simone Carreiro Vieira Karuta1,2,3, Caroline Mensor Folchini4, Mariana Millan Fachi5
1Department of Medicine Course, Pequeno Príncipe Faculdades, Curitiba, Paraná, Brazil. sizetecv@yahoo.com.br.
Insights
This study analyzed intracranial compliance in healthy children using a noninvasive device. The P2/P1 ratio, a measure of intracranial compliance, was determined in supine and seated positions.
Area of Science:
- Pediatric Neurology
- Biomedical Engineering
- Physiology
Background:
- Intracranial pressure (ICP) waveform morphology and compliance are crucial for diagnosing pediatric neurological conditions.
- Limited data exists on ICP waveform morphology in neurologically healthy children.
- Understanding normal intracranial compliance is essential for identifying pathological deviations.
Purpose of the Study:
- To analyze intracranial compliance in neurologically healthy pediatric patients using a noninvasive method.
- To establish reference values for intracranial compliance in a pediatric population.
- To evaluate patient acceptance and comfort of the noninvasive monitoring device.
Main Methods:
- An observational, cross-sectional study involving 55 neurologically healthy pediatric participants.
- Intracranial pressure waveforms were recorded using a noninvasive extracranial sensor.
- Intracranial compliance was assessed by analyzing the P2/P1 ratio in supine (0°) and seated (45°) positions.
Main Results:
- The mean P2/P1 ratio, indicative of intracranial compliance, was 0.94 (SD=0.14) in the supine position and 0.91 (SD=0.15) in the seated position.
- The noninvasive device was well-accepted by participants, with high satisfaction regarding usage time (9.8/10) and no reported discomfort.
- This study provides normative data for intracranial compliance in healthy children.
Conclusions:
- The noninvasive method effectively determined intracranial compliance values in a neurologically healthy pediatric population.
- The P2/P1 ratio serves as a viable metric for assessing intracranial compliance in children.
- This approach offers a comfortable and well-tolerated method for pediatric neurological assessments.
Abstract:
Information about the morphology of the intracranial pressure waveform, as well as the variations in intracranial pressure (ICP) and compliance in pediatric patients are essential to diagnose and predict the progression of various neurological conditions. However, there is no information on the morphology of the IP waveform in neurologically healthy pediatric patients. In the present study, intracranial compliance was therefore analyzed in neurologically healthy patients with the aid of a noninvasive device. The study was an observational, cross-sectional study. Fifty-five neurologically healthy participants were included. Data on intracranial compliance with the patient in two positions, lying down (0°) and seated (45°), were collected with a noninvasive extracranial sensor, which allowed the intracranial pressure waveforms to be recorded. The values of the ratio P2/P1 were then analyzed. A questionnaire (with a scale from zero to ten, where ten corresponds to the highest level of satisfaction) was applied for patients to evaluate their satisfaction with the sensor. Patients were 10 years old (average), and most of them were (58%). Mean P2/P1 ratio was 0.94 (sd = 0.14) in the supine position and 0.91 (sd = 0.15) in the seated position. Participants were satisfied with the length of time for which the equipment was used (9.8, sd = 0.71). The device did not cause any discomfort. The noninvasive method used was well accepted by the patients. Intracranial compliance values were determined by analysis of the P2/P1 ratio in neurologically healthy pediatric population.Trial registration: Brazilian Registry of Clinical Trials Identifier: RBR-5j74ddg.
