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[The effect of pregnancy on multiple sclerosis].
I V Zakroyshchikova1, T O Simaniv1, D O Zemlyanaya2
1Research Center of Neurology, Moscow, Russia.
Planning pregnancy with multiple sclerosis (MS) is complex due to concerns about disease-modifying treatments (DMTs). This review covers immunological changes during pregnancy and DMT risks for fertility and fetal development.
Area of Science:
- Neurology
- Immunology
- Reproductive Medicine
Background:
- Multiple sclerosis (MS) affects women of reproductive age, raising concerns about pregnancy planning and disease-modifying treatments (DMTs).
- A significant percentage of women with MS (14%) refuse pregnancy planning due to concerns about pregnancy course, outcomes, and DMT effects.
- Concerns include potential teratogenicity of DMTs, impact on fertility, and disease transmission to offspring.
Conclusions:
- Informed decisions regarding pregnancy planning for women with MS require comprehensive data on DMTs.
- Addressing concerns about DMTs, fertility, and fetal development is crucial for patient care.
- Further research may elucidate the long-term effects and optimize management strategies.
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