Related Experiment Video
Updated: Jun 15, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Enhancing Drug-Related Data Exchange: Advanced Technical Support for Interoperability
James Liang1, Jean Noel Nikiema1
1Centre de recherche en santé publique, Université de Montréal et CIUSSS du Centre-Sud-de-l'Île-de-Montréal, Montréal, Canada.
Abstract:
This paper describes the technical support services developed to facilitate the usage of the Canadian Drug Ontology (OCRx). These services include a lookup service named PaperRx, which retrieves OCRx drug entities using description logic queries (DLqueries) conducted within OCRx's classified structure. Additionally, the services feature a SPARQL endpoint, an OWL file downloader, and a RESTful Application Programming Interface. This suite of services supports the application of the Findable, Accessible, Interoperable, and Reusable (FAIR) principles to OCRx.
Related Concept Videos
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Discovery: Overview
Drug Biotransformation: Overview
Drug Administration and Therapy Phases: Overview
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Drug-Receptor Interactions
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Drug Regulation

