Microneedles-Based Theranostic Platform: From the Past to the Future

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Clinical Diagnostics

Background:

• Fully integrated theranostic devices are crucial for real-time disease monitoring and personalized medicine.
• Microneedles (MNs) are promising wearable devices for biosensing and therapy, advancing diagnostic and therapeutic platforms.
• Progress in electrochemical sensing, micronano fabrication, and biocompatible materials is key for MN-based systems.

Purpose of the Study:

• To review the advancements in integrated microneedle (MN) theranostic systems.
• To highlight the potential of MNs in clinical applications for disease monitoring and drug delivery.
• To discuss the challenges and opportunities in developing closed-loop MN systems.

Main Methods:

• Review of recent literature on microneedle technology and theranostic applications.
• Analysis of advancements in electrochemical sensing, micronano fabrication, and materials science.
• Examination of clinical trial outcomes and translational prospects.

Main Results:

• Microneedle-based closed-loop systems show enhanced detection, biocompatibility, and cost-effectiveness.
• Integration of MN chips with other biochips represents a significant area for development.
• Successful clinical trials demonstrate strong prospects for target molecule monitoring and drug delivery.

Conclusions:

• Integrated diagnostic and therapeutic MN systems hold excellent clinical translational prospects.
• Key areas for future development include continuous monitoring, intelligent control, safety, and regulatory approval.
• Microneedle technology is poised to revolutionize personalized healthcare through advanced theranostic platforms.