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Triflic Anhydride Promoted Decarboxylative Functionalization of α-Amino Acids
Mingyue Yuan1,2, Mingliang Lou2, Gen Li2
1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People's Republic of China.
Abstract:
The decarboxylation of naturally abundant amino acids, followed by subsequent inter- or intramolecular reaction cascades, enables the rapid synthesis of a variety of diverse and high-value amine derivatives. Previous methods have relied heavily on transition metals, involved tedious procedures, or required harsh conditions. Herein, we present a novel reaction cascade for the decarboxylation and nucleophilic functionalization of α-amino acids. This method is characterized by being transition-metal-free, convenient to operate, environmentally friendly and having mild conditions.
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