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Mitomycin Intravascular Chemoembolization for Corneal Neovascularization.

Daniel Chavez Velazquez1, Gustavo Ortiz-Morales, Guillermo Raul Vera-Duarte

  • 1Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico .

Cornea
|August 23, 2024
PubMed
Summary

Mitomycin C intravascular chemoembolization (MICE) effectively reduced corneal neovascularization (CNV). This novel treatment showed no immediate safety concerns, offering a promising option for CNV management.

Keywords:
MICEcorneacorneal chemoembolizationcorneal neovascularizationherpetic keratitismitomycin C

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Medical Interventions

Background:

  • Corneal neovascularization (CNV) poses a significant threat to vision, often associated with conditions like herpes simplex keratitis.
  • Existing treatments for CNV can be invasive or have limited efficacy.
  • The need for effective and safe therapeutic strategies for CNV is critical.

Purpose of the Study:

  • To evaluate the efficacy of mitomycin C intravascular chemoembolization (MICE) as a treatment for corneal neovascularization (CNV).

Main Methods:

  • A prospective, nonrandomized, interventional study involving patients with stable CNV.
  • Intravascular injection of 0.1% mitomycin C into CNV lesions under topical anesthesia.
  • Quantification of vascular regression using ImageJ software analysis of standardized clinical photographs.

Main Results:

  • Eight patients with CNV, primarily due to herpes simplex keratitis, were treated with MICE.
  • A significant reduction in vascularity was observed, with mean pixel count decreasing from 5983.41 to 2060.38 (P = 0.029).
  • No immediate complications or recurrence of CNV were noted during a median follow-up of 419.5 days; two patients successfully underwent keratoplasty post-treatment.

Conclusions:

  • Mitomycin C intravascular chemoembolization (MICE) demonstrates effectiveness in reducing corneal neovascularization.
  • The procedure appears safe in the short term, with no immediate adverse events reported.
  • Further research with larger cohorts and longer follow-up periods is warranted to ascertain long-term efficacy and visual impact.