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Updated: Jun 15, 2025
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
Published on: March 6, 2015
Intestinal Lymphatic Biology, Drug Delivery, and Therapeutics: Current Status and Future Directions
Sanjeevini Babu Reddiar1, Yining Xie1, Mohammad Abdallah1
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (S.B.R., Y.X., M.A., S.H., L.H., O.M.F., G.G., A.A., Z.L., M.A.F., I.K.S., C.J.H.P., E.C., N.L.T.); China Pharmaceutical University, Nanjing, China (S.H., L.H.); Applied Surgery and Metabolism Laboratory, School of Biological Sciences (A.R.J.P.) and Surgical and Translational Research Centre, Department of Surgery, Faculty of Medical and Health Sciences (A.R.J.P., J.A.W.), University of Auckland, Auckland, New Zealand; and Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (N.L.T.).
The intestinal lymphatic system is now understood as an active pathway for drug delivery. Novel strategies leverage this system for enhanced therapeutic benefits and drug absorption.
Area of Science:
- Gastroenterology and Pharmacology
- Lymphatic System Physiology
- Drug Delivery Systems
Background:
- Intestinal lymphatics were historically viewed as passive conduits.
- Recent research reveals their active, dynamic role in biological processes.
- This paradigm shift impacts drug and vaccine delivery strategies.
Purpose of the Study:
- To review the anatomy and physiology of the gastrointestinal lymphatic system.
- To focus on aspects relevant to intestinal lymphatic drug delivery.
- To summarize current and future strategies for drug delivery via this route.
Main Methods:
- Comprehensive literature review of lymphatic system research.
- Analysis of drug physicochemical properties influencing lymphatic transport.
- Evaluation of novel delivery systems (nanotechnology, lipid prodrugs).
Main Results:
- Demonstrated active and specific roles of intestinal lymphatics.
- Highlighted advanced drug delivery strategies utilizing lymphatic pathways.
- Showcased significant pharmacokinetic and therapeutic advantages of lymphatic delivery.
Conclusions:
- Intestinal lymphatics offer a promising route for drug and biologic delivery.
- Advanced strategies are improving drug uptake and therapeutic outcomes.
- Further development is crucial for clinical application of these delivery systems.
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