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Biofilm Formation on Denture Base Material Reinforced With a Novel Organic Material
Manoharan P S1, Jacob John2, Prashanth K3
1Department of Prosthodontics, Crown and Bridge, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Pondicherry, IND.
Cureus
|August 26, 2024
Summary
Microcrystalline cellulose (MCC) reinforced denture base resin showed increased Candida albicans biofilm formation. Further research is needed to explore antifungal agents for these novel materials.
Area of Science:
- Biomaterials Science
- Dental Materials
- Microbiology
Background:
- Microcrystalline cellulose (MCC), a novel organic material, enhances flexural strength and modulus in denture base resins.
- Concerns exist regarding the potential for organic materials to promote microbial growth, specifically Candida.
Purpose of the Study:
- To evaluate Candida albicans biofilm formation on polymethyl methacrylate (PMMA) denture base resin reinforced with MCC.
Main Methods:
- MCC was extracted from oil palm empty fruit bunch (OPEFB) fibers.
- Biofilm formation was assessed using biofilm assays and microscopy (safranin staining, SEM).
- Tested groups included MCC-reinforced PMMA, conventional PMMA, and an empty control.
Main Results:
- MCC-reinforced PMMA exhibited significantly higher Candida albicans biofilm formation (1.43 times) compared to conventional PMMA.
- Biofilms on MCC-reinforced PMMA showed heterogeneous structures with yeast, hyphae, and increased extracellular polysaccharide matrix.
Conclusions:
- Denture base resin incorporated with MCC demonstrates increased biofilm formation.
- Further investigation into antifungal agents for reinforced denture base resins is recommended.
