Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

512
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
512
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

522
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
522
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

2.0K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.0K
Hormonal Regulation01:33

Hormonal Regulation

33.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.0K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

405
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
405
Blood Pressure01:30

Blood Pressure

1.0K
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of Acute Myocardial Infarction Mortality Trends in the African American Population in the United States (1999 - 2020).

Cardiology research·2026
Same author

Early Identification of Severe COVID-19 Cases and the Need for ICU Care Based on Clinical and Laboratory Risk Factors.

Cureus·2025
Same author

Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·2025
Same author

Rheumatoid Arthritis: A Rare Cause of Pachymeningitis and Optic Neuritis.

European journal of case reports in internal medicine·2024
Same author

Vitamin B12 Deficiency in Thrombotic Thrombocytopenic Purpura-Like Cases.

European journal of case reports in internal medicine·2024
Same author

Misidentified Metastases: Diagnosing and Managing Pyogenic Liver Abscesses in a Breast Cancer Survivor.

The American journal of case reports·2024
Same journal

Retraction: The Association Between Janus Kinase 2 and Factor V Leiden Mutations and Thrombotic Complications in Patients With Myeloproliferative Disorders: A Study From Saudi Arabia.

Cureus·2026
Same journal

Patient-Reported Understanding of Emergency Department Discharge Instructions, Satisfaction, and Acceptability of a Future Telemedicine-Based Call-Back Program: Phase 1 Observational Pilot Study at a Tertiary Hospital in Dubai, United Arab Emirates.

Cureus·2026
Same journal

Correction: Methylprednisolone-Induced Delayed and Sustained Bradycardia in Multisystem Inflammatory Syndrome in Children.

Cureus·2026
Same journal

Rapid Interval Development of a Left Hepatic Artery Pseudoaneurysm During Acute Interstitial Edematous Pancreatitis.

Cureus·2026
Same journal

Recurrent Acute Pancreatitis Secondary to Untreated Hyperparathyroidism: A Case Report and Literature Review.

Cureus·2026
Same journal

A Prospective Case-Control Study of Helicobacter pylori and Systemic Inflammation in Colorectal Cancer Pathogenesis.

Cureus·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2025

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.7K

Cracking the Code: A Case Report on Low-Renin Hypertension.

Fawwad A Ansari1, Bilal Hamid2, Inemesit Akpan1

  • 1Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.

Cureus
|August 26, 2024
PubMed
Summary
This summary is machine-generated.

Low-renin hypertension (LRH) is a spectrum of conditions causing high blood pressure with low renin. This case highlights effective treatment with spironolactone for resistant LRH.

Keywords:
low-renin hypertensionprimary hyperaldosteronismresistant hypertensionsecondary hypertensionspironolactone

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.1K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.6K

Related Experiment Videos

Last Updated: Jun 15, 2025

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.7K
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.1K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.6K

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiology

Background:

  • Low-renin hypertension (LRH) presents as hypertension with suppressed serum renin levels.
  • LRH encompasses a range of conditions, including essential hypertension and secondary causes.

Observation:

  • A 57-year-old female with resistant hypertension was evaluated for secondary causes.
  • Diagnostic workup revealed low renin levels and normal aldosterone.
  • The patient had been on multiple antihypertensive medications without adequate blood pressure control.

Findings:

  • Spironolactone therapy was initiated for the patient.
  • Rapid and effective blood pressure normalization was observed following spironolactone treatment.
  • This suggests a favorable response to mineralocorticoid receptor antagonism in this LRH case.

Implications:

  • LRH is an under-recognized cause of difficult-to-control hypertension.
  • Early identification and specific treatment strategies can improve patient outcomes.
  • Mineralocorticoid receptor blockers and ENaC blockers show promise in managing LRH.