Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

170
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
170
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

1.4K
An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
1.4K
Dementia01:30

Dementia

107
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
107

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reaction time as a performance validity measure in older adults with and without early-stage Alzheimer's disease.

Applied neuropsychology. Adult·2026
Same author

Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.

Journal of the American Heart Association·2026
Same author

Feasibility and validity of the D-Cog: A novel digital spatial working memory test for dementia assessment.

Journal of Alzheimer's disease : JAD·2026
Same author

Novel H<sub>2</sub> colourimetric indicator for screening the activity of H<sub>2</sub>-generating bacteria and measuring their total viable count (TVC).

The Analyst·2026
Same author

Relationship Between Hematoma Location and Underlying Small Vessel Disease in Cerebellar Intracerebral Hemorrhage.

Neurology·2026
Same author

Lifelong trajectories of modifiable vascular risk factors and relation to cerebral small vessel disease in the Framingham Heart Study.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jun 15, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
09:33

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

7.9K

An Interprofessional Team for Disease-Modifying Therapy in Alzheimer Disease Implementation.

Katherine W Turk1, Mark D Knobel1, Alexandra Nothern1

  • 1Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA.

Neurology. Clinical Practice
|August 26, 2024
PubMed
Summary

New amyloid-targeting immunotherapies like lecanemab offer Alzheimer disease treatment promise but carry risks. This study shares resources developed for safe lecanemab infusion implementation and monitoring at a major medical center.

More Related Videos

Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

487
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

118

Related Experiment Videos

Last Updated: Jun 15, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
09:33

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

7.9K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

487
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

118

Area of Science:

  • Neuroscience
  • Immunotherapy
  • Alzheimer Disease Therapeutics

Background:

  • Alzheimer disease treatment landscape is evolving with new amyloid-targeting immunotherapies.
  • Lecanemab shows promise but carries significant patient risks requiring careful management.
  • Effective clinical implementation necessitates robust protocols and patient monitoring.

Purpose of the Study:

  • To develop and share practical resources for the safe administration of lecanemab.
  • To streamline the process of lecanemab infusion and monitoring in a clinical setting.
  • To provide a model for other healthcare centers implementing novel Alzheimer therapies.

Main Methods:

  • Convened an interprofessional team to address lecanemab infusion logistics.
  • Developed patient education materials and clinical documentation templates.
  • Established systems and processes for infusion monitoring and management.

Main Results:

  • Created a comprehensive set of resources for lecanemab administration.
  • Designed adaptable templates and protocols for clinical use.
  • Facilitated the safe integration of lecanemab into patient care pathways.

Conclusions:

  • The developed resources and processes support the safe and effective implementation of lecanemab.
  • Sharing these materials can aid other institutions in managing amyloid-targeting immunotherapies.
  • Interprofessional collaboration is key to navigating the complexities of new Alzheimer treatments.