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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

179
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

245
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
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Preparation of Binary and Ternary Deep Eutectic Systems
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Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery.

Anshu Sharma1, Yea Rock Park1, Aman Garg2,3

  • 1Department of Chemical Engineering, Kangwon National University, Chuncheon, Kangwon 24341, Republic of Korea.

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Deep eutectic solvents (DES) offer eco-friendly solutions for dissolving bioactive compounds, enhancing drug formulation by improving solubility and stability. These advanced DES strategies promise better drug delivery and extended shelf life for pharmaceuticals.

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Area of Science:

  • Green Chemistry
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Deep eutectic solvents (DES) are emerging as sustainable alternatives to traditional solvents.
  • Their tunable properties allow for customization to specific biomolecules and active pharmaceutical ingredients (APIs).
  • Poor solubility of APIs remains a significant challenge in drug formulation and delivery.

Purpose of the Study:

  • To explore novel strategies utilizing DES for efficient API extraction.
  • To address the limitations of poor API solubility in pharmaceutical development.
  • To investigate the impact of DES on the chemical and physical stability of APIs.

Main Methods:

  • Review of emerging DES-based approaches for API solubility enhancement.
  • Analysis of DES's role in modifying API characteristics.
  • Evaluation of DES potential for improving drug shelf life and therapeutic benefits.

Main Results:

  • DES demonstrate significant potential in overcoming API solubility challenges.
  • Customizable DES can be tailored to enhance the dissolution of various bioactive compounds.
  • DES application can positively influence API stability, potentially extending drug efficacy.

Conclusions:

  • DES represent a promising green technology for advanced pharmaceutical formulations.
  • Developing DES-based methods can lead to improved drug solubility, stability, and delivery.
  • Further research into DES applications is crucial for unlocking their full potential in medicine.