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Related Concept Videos

Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
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G-protein Coupled Receptors01:21

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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GPCR Desensitization01:12

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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Jun 15, 2025

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G Protein-Coupled Receptors in Skin Aging.

Suet Ting Cheung1, Yelim Do1, Eunah Kim1

  • 1The Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; The Biotechnology Research Institute, The Hong Kong University of Science and Technology, Hong Kong, China.

The Journal of Investigative Dermatology
|August 26, 2024
PubMed
Summary
This summary is machine-generated.

G protein-coupled receptors (GPCRs) are key regulators of skin aging, influencing elasticity, texture, and pigmentation. Targeting these receptors offers potential for new anti-aging treatments.

Keywords:
G protein–coupled receptorsInflammatory skin diseasePhotoagingSkin aging

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Area of Science:

  • Dermatology and Molecular Biology
  • G protein-coupled receptor (GPCR) research

Background:

  • Skin aging is a multifaceted process influenced by internal and external factors.
  • G protein-coupled receptors (GPCRs) are crucial in modulating skin functions and aging.
  • Understanding GPCR roles is vital for addressing age-related skin changes.

Purpose of the Study:

  • To catalog skin-expressed GPCRs and review their involvement in skin aging.
  • To explore the potential of GPCRs as therapeutic targets for aging skin.

Main Methods:

  • Comprehensive literature review and cataloging of GPCRs expressed in human skin.
  • Analysis of GPCR functions related to pigmentation, elasticity, texture, and disorders.

Main Results:

  • Identified 156 distinct GPCRs expressed in the skin.
  • Detailed the roles of these GPCRs in various aspects of skin aging, including wrinkles and texture.
  • Highlighted GPCR involvement in aging-associated skin conditions.

Conclusions:

  • GPCRs are significant regulators of the skin aging process.
  • Targeting specific GPCRs with ligands presents a promising avenue for developing novel anti-aging therapies.
  • Further research into skin GPCRs can lead to effective treatments for age-related dermatological issues.