Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

5.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Barriers and facilitators to intracerebral haemorrhage platform trial recruitment: a survey of stroke clinicians.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Rates, risks and routes to reduce vascular dementia (R4VaD), a UK-wide multicentre prospective observational cohort study of cognition after stroke: baseline data and statistical analysis plan (ISRCTN18274006).

Cerebrovascular diseases extra·2026
Same author

Dual Antiplatelet Therapy and Immediate Intensive Statin in Mild Ischemic Stroke: A Randomized Trial.

Neurology·2026
Same author

Effect of tranexamic acid for acute spontaneous intracerebral haemorrhage: a systematic review and individual patient data meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

Syndemic analysis of stroke in Indonesia.

The Lancet regional health. Western Pacific·2026
Same author

One-year functional outcome of the Flying Intervention Team versus patient interhospital transfer in acute ischaemic stroke.

European stroke journal·2026

Related Experiment Video

Updated: Jun 15, 2025

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

11.0K

Comorbidities and Angiogenic Regulators Affect Endothelial Progenitor Cell Subtype Numbers in a Healthy Volunteer

Kamini Rakkar1, Rais Reskiawan A Kadir2, Othman A Othman3

  • 1Translational Medical Sciences, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.

Stem Cell Reviews and Reports
|August 26, 2024
PubMed
Summary

Endothelial progenitor cell (EPC) numbers and function are influenced by factors like diabetes, sex, and age. Angiogenic regulators also correlate with EPC subtypes, highlighting the complexity of EPCs in vascular health.

Keywords:
Angiogenic regulatorsDiabetesEndothelial progenitor cellsInflammation

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.4K
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.1K

Related Experiment Videos

Last Updated: Jun 15, 2025

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

11.0K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.4K
Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood
07:26

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

11.1K

Area of Science:

  • Cardiovascular Biology
  • Stem Cell Research
  • Regenerative Medicine

Background:

  • Endothelial progenitor cells (EPCs) are crucial for repairing blood vessels via neovascularization.
  • EPCs are investigated for their diagnostic, prognostic, and therapeutic potential in ischemic diseases like stroke.
  • Understanding EPC activation, homing, and migration in stroke patients remains incomplete.

Purpose of the Study:

  • To profile EPC numbers, subtypes, and function in a non-stroke control group.
  • To analyze demographic, clinical, and plasma angiogenic regulator correlations with EPC characteristics.
  • To identify factors influencing EPCs in vascular health.

Main Methods:

  • Analysis of demographic and clinical data from the Dunhill Medical Trust Endothelial Progenitor Cell Study control group.
  • Quantification of EPC numbers and subtypes (e.g., CD45-CD34+CD133+KDR+, CD34+KDR+, KDR+).
  • Measurement of plasma levels of angiogenic regulators and correlation analysis with EPC parameters.

Main Results:

  • Diabetes was associated with significantly suppressed EPC numbers and specific EPC subtypes.
  • Male participants exhibited lower EPC numbers compared to females.
  • EPC proliferative capacity decreased with increasing age.
  • Pro-angiogenic factors correlated positively with EPC subtypes, while anti-angiogenic factors showed mixed correlations.

Conclusions:

  • EPC numbers and subtypes are significantly influenced by comorbidities (e.g., diabetes), sex, and age.
  • Plasma angiogenic regulators show differential correlations with EPC subtypes.
  • Larger studies are needed to fully understand the interactions between comorbidities, biomarkers, and EPCs in vascular health.