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BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations

Mariaelena Valentino1, Matteo Malinverno1, Claudio Maderna1

  • 1IFOM ETS, AIRC Institute of Molecular Oncology, Milan, Italy (M.V., M.M., C.M., F.Z., G.R., M.G.L., E.D., M.P.).

Circulation
|August 26, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
cerebral cavernous malformationsendothelium drug therapypolycomb repressive complexes

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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
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