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Inheritance patterns of lower urinary tract symptoms in adults: a systematic review
Lorcan Moore1, Sachin Malde2, Prokar Dasgupta1,2
1Guy's King's and St Thomas' School of Medical Education, King's College London, London, UK.
BJU International
|August 27, 2024
Summary
Lower urinary tract symptoms (LUTS) show genetic links, particularly for benign prostatic enlargement and some incontinence types. Inheritance patterns vary, with overactive bladder and stress incontinence having less clear genetic ties.
Area of Science:
- Urology
- Genetics
- Epidemiology
Background:
- Lower urinary tract symptoms (LUTS) are common in adults.
- Understanding the genetic basis of LUTS is crucial for developing targeted therapies.
- Previous research on LUTS heritability has been fragmented.
Purpose of the Study:
- To systematically review and synthesize evidence on the heritability and inheritance patterns of LUTS in adult populations.
- To identify specific LUTS with significant genetic predisposition.
Main Methods:
- A comprehensive literature search was conducted across five major databases.
- 34 studies were included based on predefined eligibility criteria, focusing on heritability, gene frequencies, and familial aggregation.
- Data synthesis followed PRISMA guidelines, with study quality assessed using ROBINS-I and JBI checklists.
Main Results:
- Benign prostatic enlargement (BPE) symptoms, mixed and urge urinary incontinence (MUI/UUI), isolated nocturia, and isolated frequency showed associations with genetic predisposition.
- Overactive bladder (OAB) and stress urinary incontinence (SUI) demonstrated more modest inheritance patterns.
- The reviewed studies covered various LUTS, including general LUTS, BPE, UI subtypes, nocturia, OAB, and other specific symptoms.
Conclusions:
- The underlying mechanisms of LUTS are diverse and complex.
- Genetic factors play a role in the manifestation of several LUTS.
- Further research is needed to comprehensively elucidate the inheritance patterns of LUTS.
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