Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Light chain disease and massive proteinuria.

F Lessard, P Bannon, R Lepage

    Clinical Chemistry
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer.

    Cell cycle (Georgetown, Tex.)·2023
    Same author

    Sci-Sat AM: Brachy - 07: Plastic scintillation detector validation for kV dosimetry.

    Medical physics·2017
    Same author

    Abnormality of standing posture improves in patients with bilateral spastic cerebral palsy following lower limb surgery.

    Gait & posture·2017
    Same author

    Functional testosterone: biochemical assessment of hypogonadism in men--report from a multidisciplinary workshop hosted by the Ontario Society of Clinical Chemists.

    The aging male : the official journal of the International Society for the Study of the Aging Male·2007
    Same author

    The first preclinical pharmacotoxicological safety assessment of CGS 35601, a triple vasopeptidase inhibitor, in chronically instrumented, conscious, and unrestrained spontaneously hypertensive rats.

    Drug and chemical toxicology·2006
    Same author

    Two new peptides to improve post-operative gastric ileus in dog.

    Peptides·2003

    This case study details a 64-year-old man with lambda light chain disease, experiencing panhypogammaglobulinemia, anemia, and severe Bence Jones proteinuria leading to renal failure. The study highlights the critical role of light chains in kidney function.

    Area of Science:

    • Nephrology
    • Hematology
    • Immunology

    Background:

    • Light chain diseases are a spectrum of plasma cell dyscrasias characterized by the overproduction of immunoglobulin light chains.
    • These conditions can lead to a variety of systemic complications, including renal impairment.

    Observation:

    • A 64-year-old male presented with symptoms indicative of a complex hematologic and renal disorder.
    • The patient exhibited panhypogammaglobulinemia, anemia, and significant Bence Jones proteinuria (24.6 g/L).

    Findings:

    • The patient was diagnosed with lambda type light chain disease.
    • Serum analysis confirmed the presence of lambda type light chains.
    • The clinical presentation was marked by the association of panhypogammaglobulinemia with anemia, massive proteinuria, and renal failure.

    Related Experiment Videos

    Implications:

    • This case underscores the severe nephrotoxic potential of monoclonal light chains.
    • Understanding the pathogenesis of light chain-associated nephropathy is crucial for timely diagnosis and management.
    • Early detection and intervention may be key to preventing irreversible renal damage in light chain disease.