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Published on: January 28, 2020
The relationship between system inflammation response index and coronary heart disease: a cross-sectional study
Tian Yang Zhang1, Hai Long Chen1, Yanyu Shi1
1College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Insights
The system inflammation response index (SIRI) is linked to a higher risk of coronary heart disease (CHD). This association is particularly notable in women, suggesting SIRI as a potential biomarker for CHD risk.
Area of Science:
- Cardiovascular Research
- Inflammation Biomarkers
- Public Health
Background:
- Coronary heart disease (CHD) is a prevalent chronic condition often linked to inflammatory processes.
- The system inflammation response index (SIRI) has emerged as a novel biomarker for systemic inflammation.
Purpose of the Study:
- To investigate the association between SIRI and the risk of developing CHD.
- To explore this relationship using data from the National Health and Nutrition Examination Survey (NHANES).
Main Methods:
- A cross-sectional study analyzing NHANES data from 2007-2016 for participants aged 40 and above.
- Logistic regression and restricted cubic spline (RCS) analyses were employed to assess the SIRI-CHD relationship.
- Stratified subgroup analyses were performed to examine interactions across various demographic and clinical factors.
Main Results:
- Elevated SIRI levels were significantly associated with an increased risk of CHD (OR 1.12, 95% CI: 1.03-1.22).
- A significant interaction between SIRI and CHD risk was observed in females, but not in other subgroups.
- A linear relationship between SIRI and CHD risk was confirmed, with no evidence of non-linearity.
Conclusions:
- An elevated SIRI is a significant indicator of increased CHD risk.
- The association between SIRI and CHD is particularly pronounced in women.
- SIRI may serve as a valuable inflammatory biomarker for assessing CHD risk stratification.
Background:
Coronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, the system inflammation response index (SIRI) has aroused researchers' interest as a novel inflammatory biomarker. This study aims to explore the relationship between the SIRI and CHD through the National Health and Nutrition Examination Survey (NHANES) database.
Methods:
We conducted a cross-sectional study and analyzed participants aged 40 and above with complete data from the NHANES survey years 2007-2016. Logistic regression analysis was used in this study to explore the relationship between the risk of CHD and SIRI. Stratified subgroup analysis was conducted based on age, gender, race, education level, body mass index (BMI), smoking status, drinking, hypertension, diabetes and angina pectoris to evaluate the relationship between SIRI and CHD in different populations. Additionally, restricted cubic spline (RCS) analysis was employed to investigate whether there is a nonlinear association between SIRI and CHD.
Results:
A total of 6374 eligible participants were included, among whom 387 were diagnosed with CHD. The SIRI levels in the CHD group were significantly higher than those in the non-CHD group. After adjusting for potential confounders, an elevated SIRI level was associated with an increased risk of CHD, with an odds ratio of 1.12, 95% CI: (1.03, 1.22), P = 0.008. Subgroup analysis results indicated a significant interaction between SIRI and CHD among genders (P for interaction <0.05), especially in females. In contrast, no significant interaction was observed among age, race, education level, BMI, smoking status, drinking, hypertension, diabetes and angina pectoris (P for interaction >0.05). The RCS analysis showed a significant linear relationship between SIRI and CHD (P for non-linearity >0.05), with an inflection point at 2.86.
Conclusion:
Our study indicates that an elevated system inflammation response index is associated with a higher risk of CHD. Particularly among women.
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