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Exploring the gut microbiota's effect on temporomandibular joint disorder: a two-sample Mendelian randomization
Kai Zhao1, Shuaiqi Ji2, Han Jiang1
1Department of Stomatology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, China.
Frontiers in Cellular and Infection Microbiology
|August 27, 2024
Summary
This study investigated the gut microbiota
Area of Science:
- Microbiome research
- Genetics
- Human health
Background:
- Temporomandibular joint disorders (TMD) are common.
- Gut microbiota influences many diseases.
- The link between gut microbiota and TMD is not well understood.
Purpose of the Study:
- To explore the causal relationship between gut microbiota and TMD.
- To identify specific gut bacteria associated with TMD risk or protection.
Main Methods:
- Utilized Genome-Wide Association Studies (GWAS) data for gut microbiota and TMD.
- Employed Mendelian randomization analysis with multiple mathematical models.
- Conducted sensitivity and reverse Mendelian analyses for robust findings.
Main Results:
- Identified specific gut bacteria as risk factors for TMD, including Coprobacter and Ruminococcus torques group.
- Found protective effects of Peptococcaceae against TMD.
- Highlighted several other bacterial taxa associated with TMD risk.
Conclusions:
- Established a link between gut microbiota composition and TMD.
- Provided insights into TMD pathogenesis.
- Suggested potential microbial targets for TMD therapeutic strategies.
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