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Ya-Jing Chen1,2,3, Li-Hua Jia2, Tao-Hong Han3

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Current osteoporosis drugs have limitations. This review explores traditional Chinese medicine and acupuncture as potential treatments, highlighting the need for better understanding of their mechanisms for improved drug development.

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Traditional Chinese Medicine

Background:

  • Osteoporosis is a metabolic bone disease causing decreased bone density and increased fracture risk.
  • Current pharmacological treatments often have single targets and significant side effects.
  • Traditional Chinese Medicine (TCM) and acupuncture show promise but require further mechanistic understanding.

Purpose of the Study:

  • To review current and developing anti-osteoporosis drugs.
  • To explore the potential of TCM and acupuncture in osteoporosis treatment.
  • To identify knowledge gaps in osteoporosis pathogenesis for improved drug development.

Main Methods:

  • Literature review of pharmacological treatments for osteoporosis.
  • Analysis of existing research on TCM and acupuncture for osteoporosis.
  • Identification of key molecular pathways and targets in osteoporosis pathogenesis.

Main Results:

  • Current anti-osteoporosis drugs primarily inhibit bone resorption or promote bone formation, with limitations.
  • TCM and acupuncture offer potential advantages, including immune system regulation.
  • Understanding the specific molecular mechanisms of TCM is crucial for therapeutic advancement.

Conclusions:

  • A comprehensive understanding of osteoporosis pathogenesis is vital for developing effective therapeutic targets.
  • Further research into TCM and acupuncture mechanisms is needed to overcome limitations of current osteoporosis treatments.
  • This review provides a basis for future pharmacological research and new drug development in osteoporosis.