An intelligent NIR-IIb-responsive lanthanide@metal-organic framework core-shell nanocatalyst for combined deep-tumor...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Photodynamic therapy (PDT) and photothermal therapy (PTT) show promise for cancer treatment.
• Current limitations include shallow light penetration and low photosensitizer loading capacity.

Purpose of the Study:

• To develop a multifunctional nanocomposite for integrated PDT and PTT.
• To overcome limitations of existing cancer therapies through deep-tissue treatment.

Main Methods:

• Constructed an upconversion nanoparticle@Zr-based metal-organic framework@indocyanine green molecule (UCNPs@ZrMOF@ICG) nanocomposite.
• Utilized 1532 nm light for upconversion luminescence and deep-tissue PDT.
• Employed 808 nm near-infrared light for PTT via indocyanine green.

Main Results:

• The UCNPs@ZrMOF@ICG nanocomposite efficiently integrated PDT and PTT.
• Achieved deep-tissue PDT through upconversion luminescence and ZrMOF catalysis.
• Demonstrated effective PTT with a photothermal conversion efficiency of ~28%.

Conclusions:

• The developed nanosystem facilitates efficient deep-tissue tumor treatment by combining PDT and PTT.
• This multifunctional nanocomposite offers a personalized approach to cancer therapy.