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Macular choroidal thickness in keratoconus.

Ali Abbasi Mehrabadi1, Javad Sadeghi2, Nasser Shoeibi2

  • 1Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran.

Clinical & Experimental Optometry
|August 27, 2024
PubMed
Summary
This summary is machine-generated.

Keratoconus patients exhibit significantly thicker choroids compared to those with myopia-astigmatism or emmetropia. This finding suggests potential inflammatory mechanisms contributing to choroidal changes in keratoconus.

Keywords:
Choroidal thicknessemmetropiakeratoconusmyopiaoptical coherence tomography

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Area of Science:

  • Ophthalmology
  • Ocular Imaging
  • Corneal Diseases

Background:

  • Keratoconus is a progressive thinning of the cornea.
  • Understanding ocular structure changes in keratoconus is crucial for patient management.
  • Choroidal thickness differences in keratoconus are not well-established.

Purpose of the Study:

  • To compare choroidal thickness in keratoconus patients versus control groups.
  • To investigate potential ocular structural differences beyond the cornea.

Main Methods:

  • A case-control study included 50 keratoconus, 50 myopic-astigmatism, and 30 emmetropic individuals (18-39 years).
  • Choroidal thickness was measured using spectral-domain optical coherence tomography with enhanced depth imaging.
  • Measurements were taken at subfoveal, nasal, and temporal locations relative to the fovea.

Main Results:

  • Keratoconus patients had significantly thicker choroids at all measured locations (subfoveal, nasal, temporal) compared to both control groups (p < 0.001).
  • Mean subfoveal choroidal thickness was 396 ± 14 μm in keratoconus, 314 ± 12 μm in myopic-astigmatism, and 320 ± 18 μm in emmetropia.
  • Mean temporal and nasal choroidal thicknesses also showed significant increases in the keratoconus group.

Conclusions:

  • Choroidal thickness is significantly increased in individuals with keratoconus.
  • The underlying mechanism for this thickening is currently unknown.
  • Inflammatory processes are hypothesized as a potential cause for increased choroidal thickness in keratoconus.