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Related Experiment Video

Updated: May 6, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Association of the TGF-beta1 polymorphism with primary open-angle glaucoma: a case-control study.

Akbar Derakhshan1, Mohammad Javad Zia1, Jalil Tavakkol Afshari2,3

  • 1Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Medical Hypothesis, Discovery & Innovation Ophthalmology Journal
|May 5, 2026
PubMed
Summary
This summary is machine-generated.

This study found no significant association between the TGF-beta1 gene polymorphism at -800 G>A and primary open-angle glaucoma (POAG) in Iranian patients. The A allele is not a risk factor for POAG in this population.

Keywords:
-800 G>APCRRFLPTGF-beta-1gene polymorphismgenetic association studypolymerase chain reactionsprimary open angle glaucomarestriction fragment length polymorphismsrs1800468transforming growth factor-beta1

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Last Updated: May 6, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

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Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Primary open-angle glaucoma (POAG) is linked to reduced aqueous humor outflow.
  • Transforming growth factor beta-1 (TGF-beta1) influences extracellular matrix remodeling in the trabecular meshwork, impacting outflow facility.
  • The TGF-beta1 gene's -800 G>A polymorphism (rs1800468) was investigated for its role in POAG pathogenesis.

Purpose of the Study:

  • To investigate the association between the TGF-beta1 gene polymorphism at position -800 G>A (rs1800468) and POAG.
  • To determine if the TGF-beta1 -800 G>A polymorphism is a risk factor for POAG in patients from Khorasan Razavi Province, Iran.

Main Methods:

  • A case-control study design was employed.
  • 105 POAG patients and 105 age-matched healthy controls were recruited.
  • DNA was extracted and genotyped for the TGF-beta1 -800 G>A polymorphism using PCR-RFLP.

Main Results:

  • No significant differences in genotype frequencies (GG, GA, AA) were found between POAG cases and controls (P > 0.05).
  • Allele frequencies (G vs. A) also showed no significant association with POAG (P > 0.05).
  • Statistical analyses across various inheritance models (codominant, dominant, recessive, overdominant) revealed no significant associations.

Conclusions:

  • The TGF-beta1 -800 G>A polymorphism does not appear to be significantly associated with the development of POAG in the studied Iranian population.
  • Inheritance of the mutant A allele of TGF-beta1 at -800 is not identified as a risk factor for POAG in northeastern Iran.