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Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

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Case 332.

Cameron Adler¹, Christine Menias¹

¹From the Department of Radiology, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054.

|August 27, 2024

Summary

This summary is machine-generated.

This case study details a patient with recurrent sarcomatoid renal cell carcinoma treated with pazopanib and stereotactic radiation. Surveillance imaging revealed disease progression despite treatment, highlighting challenges in managing advanced renal cell carcinoma.

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Area of Science:

Oncology
Medical Imaging
Pharmacology

Background:

A 65-year-old male with a history of sarcomatoid renal cell carcinoma and prior nephrectomy presented with recurrent disease.
Treatment included maximum-dose pazopanib and palliative stereotactic body radiation therapy to the recurrence site.

Observation:

The patient experienced diarrhea requiring loperamide, along with abdominal pain, one month after initiating pazopanib.
Laboratory results showed a low serum total protein and elevated alkaline phosphatase.
Vital signs and white blood cell count remained within normal limits.

Findings:

Surveillance imaging, performed 7 months after pazopanib initiation and shortly after radiation therapy completion, revealed recurrent disease.
The imaging was a contrast-enhanced CT of the abdomen and pelvis in the venous phase.

Implications:

This case highlights the challenges in managing recurrent sarcomatoid renal cell carcinoma.
Further investigation into treatment efficacy and side effect management in such cases is warranted.
Understanding treatment response and progression patterns is crucial for optimizing patient care.