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Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
Published on: March 20, 2017
Ferrocene-Mediated Electrochemical Polycyclization of Malonates
Antoine Lefevre1, Régis Guillot1, Cyrille Kouklovsky1
1Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Saclay et CNRS, Bâtiment Henri Moisson, 17 Avenue des Sciences, 91400 Orsay, France.
Abstract:
We report access to the core of biologically relevant aromatic abietane diterpenoids and to the formal synthesis of podocarpic and lambertic acids or γ-lactones via an electrochemical bicyclization process initiated by the ferrocene-mediated anodic oxidation of a malonate via single electron-transfer. This approach permits escaping the use of excess of oxidants such as Mn(OAc)3 and the associated complicated purification.
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