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Related Experiment Videos

Bupropion--an antidepressant without sexual pathophysiological action.

E A Gardner, J A Johnston

    Journal of Clinical Psychopharmacology
    |February 1, 1985
    PubMed
    Summary

    Bupropion, a novel antidepressant, shows promise in resolving sexual dysfunction in patients previously treated with other antidepressants. This study suggests bupropion has a low risk of causing adverse sexual side effects.

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Sexual dysfunction is a common adverse effect of many antidepressant medications.
    • Alternative treatments with a better side effect profile are needed.

    Observation:

    • Forty male outpatients were treated with bupropion (300-600 mg/day) for 4-26 months.
    • Twenty-eight patients had a history of sexual dysfunction with prior antidepressants (tricyclic, MAOI, maprotiline, trazodone).
    • Twelve patients had no prior sexual dysfunction history.

    Findings:

    • Bupropion resolved adverse sexual effects in 24 of 28 patients (85.7%).
    • Normal sexual functioning was maintained in 12 patients with no prior sexual dysfunction.
    • Four patients did not improve sexually; two had diabetes, and two had lifelong impairments.

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    Implications:

    • Bupropion demonstrates a low propensity for inducing adverse sexual side effects.
    • This antidepressant may be a suitable alternative for patients experiencing sexual dysfunction with other treatments.
    • Further research is warranted to confirm these findings in larger, controlled studies.