Related Experiment Video
Updated: Jun 15, 2025
08:42
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
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Brain mechanisms of rumination and negative self-referential processing in adolescent depression
Laura Murray1, Nigel M Jaffe2, Anna O Tierney2
1Cognitive and Pharmacological Neuroimaging Unit, National Institute on Drug Abuse, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, United States of America; McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States of America.
Journal of Affective Disorders
|August 27, 2024
Summary
Adolescents with higher rumination showed biases toward negative information, endorsing and recalling more negative words. Increased insula reactivity may link rumination to negative memory biases in depression.
Area of Science:
- Neuroscience
- Psychology
- Cognitive Science
Background:
- Depression is associated with cognitive biases favoring negative self-relevant information.
- Rumination, characterized by repetitive negative thinking, may drive these biases.
Purpose of the Study:
- To investigate the relationship between rumination and cognitive biases in adolescents.
- To explore the neural mechanisms underlying these biases using functional magnetic resonance imaging (fMRI).
Main Methods:
- 159 adolescents (12-18 years) with varying depression symptoms underwent fMRI during a self-referent encoding task (SRET).
- Associations between self-report and ecological momentary assessment (EMA) of rumination and neural/behavioral responses were analyzed.
Main Results:
- Higher rumination correlated with endorsing/recalling more negative and fewer positive words.
- Increased self-reported rumination linked to better recognition of negative words and heightened insula/dorsal anterior cingulate activity for negative vs. positive words.
Conclusions:
- Adolescent rumination is linked to negative memory biases and altered neural responses.
- Enhanced insula reactivity may mediate the connection between rumination and negative memory biases, offering insight into depression's neurocognitive underpinnings.
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