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Patient-derived organoid models to decode liver pathophysiology.
Benjamin J Dwyer1, Janina E E Tirnitz-Parker1
1Curtin Medical School and Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia; Liver Cancer Collaborative, Perth, WA, Australia; www.livercancercollaborative.au.
Trends in Endocrinology and Metabolism: TEM
|August 27, 2024
Summary
Patient-derived liver organoids are crucial for understanding liver diseases and developing personalized medicine. These advanced models offer insights into various liver conditions, from injury to cancer, aiding therapeutic development.
Area of Science:
- Hepatology
- Regenerative Medicine
- Biotechnology
Background:
- Liver diseases pose a growing global health challenge, worsened by rising obesity and metabolic disorders.
- Patient-specific in vitro liver models are increasingly needed for regulatory compliance and therapeutic development.
- Organoid models derived from liver tissues offer a faithful recapitulation of liver biology.
Purpose of the Study:
- To review state-of-the-art patient-derived liver organoid models.
- To discuss recent technological advancements in liver organoid development and analysis.
- To explore strategies for enhancing the clinical impact of liver organoid models.
Main Methods:
- Establishment of organoid models from non-malignant and malignant liver tissues.
- Utilizing advanced understanding of liver microenvironments and innovative biomaterials.
- Employing advanced imaging techniques for comprehensive data analysis.
Main Results:
- Liver organoids provide insights into diverse liver conditions, including acute injuries, chronic diseases, and cancer.
- Technological advancements facilitate detailed analysis of liver organoid models.
- These models are pivotal for advancing personalized medicine in hepatology.
Conclusions:
- Patient-derived liver organoids are essential tools for understanding liver disease mechanisms.
- Technological progress is enhancing the utility and clinical relevance of liver organoids.
- Liver organoids represent a promising avenue for personalized therapeutic strategies in liver disease.
