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[Clinical Features and Prognosis of Secondary Intestinal Diffuse Large B-Cell Lymphoma]
Xiao-Jun Chen1,2, Su-Xia Lin1, Dong-Hui Gan1
1Department of Hematology and Rheumatology, The Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|August 27, 2024
Summary
Secondary intestinal diffuse large B-cell lymphoma (SI-DLBCL) primarily affects middle-aged men and presents with non-specific symptoms. The Lugano stage is a key independent prognostic factor for overall survival (OS) and progression-free survival (PFS) in SI-DLBCL patients.
Area of Science:
- Hematology
- Oncology
- Clinical Pathology
Context:
- Secondary intestinal diffuse large B-cell lymphoma (SI-DLBCL) is a rare extranodal non-Hodgkin lymphoma.
- Understanding its clinical features and prognostic factors is crucial for improving patient outcomes.
- This study analyzes data from 138 SI-DLBCL patients treated at a single center.
Purpose:
- To investigate the clinical characteristics, treatment patterns, and prognostic factors of SI-DLBCL.
- To identify independent predictors of overall survival (OS) and progression-free survival (PFS).
- To provide insights for the diagnosis and management of rare site lymphomas.
Summary:
- The study included 138 patients with SI-DLBCL, predominantly middle-aged men (61.59%).
- Clinical manifestations were non-specific; R-CHOP chemotherapy was the main first-line treatment.
- Five-year OS and PFS rates were 34.06% and 32.61%, respectively.
- Multivariate analysis identified Lugano stage as an independent prognostic factor for both OS and PFS.
Impact:
- Highlights the non-specific presentation of SI-DLBCL, emphasizing the need for high clinical suspicion.
- Confirms the Lugano stage as a critical independent prognostic indicator in SI-DLBCL.
- Provides valuable data for refining treatment strategies and prognostic assessments in rare lymphomas.
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