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Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative
Yang-Zhou Zhang1, Hua Gong2, Juan Yang2
1Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital, Central South University,Changsha 410008, Hunan Province, China.
Background:
Non-proliferative diabetic retinopathy (NPDR) poses a significant challenge in diabetes management due to its microvascular changes in the retina. Laser photocoagulation, a conventional therapy, aims to mitigate the risk of progressing to proliferative diabetic retinopathy (PDR).
Aim:
To compare the efficacy and safety of multi-spot vs single-spot scanning panretinal laser photocoagulation in NPDR patients.
Methods:
Forty-nine NPDR patients (86 eyes) treated between September 2020 and July 2022 were included. They were randomly allocated into single-spot (n = 23, 40 eyes) and multi-spot (n = 26, 46 eyes) groups. Treatment outcomes, including best-corrected visual acuity (BCVA), central macular thickness (CMT), and mean threshold sensitivity, were assessed at predetermined intervals over 12 months. Adverse reactions were also recorded.
Results:
Energy levels did not significantly differ between groups (P > 0.05), but the multi-spot group exhibited lower energy density (P < 0.05). BCVA and CMT improvements were noted in the multi-spot group at one-month post-treatment (P < 0.05). Adverse reaction incidence was similar between groups (P > 0.05).
Conclusion:
While energy intensity and safety were comparable between modalities, multi-spot scanning demonstrated lower energy density and showed superior short-term improvements in BCVA and CMT for NPDR patients, with reduced laser-induced damage.
Insights
Multi-spot scanning panretinal laser photocoagulation offers improved visual acuity and reduced retinal thickness in non-proliferative diabetic retinopathy (NPDR) patients compared to single-spot treatment. Both methods show similar safety profiles.
Area of Science:
- Ophthalmology
- Diabetic Retinopathy Research
- Laser Therapy
Background:
- Non-proliferative diabetic retinopathy (NPDR) is a significant complication of diabetes, characterized by retinal microvascular changes.
- Conventional laser photocoagulation aims to prevent progression to proliferative diabetic retinopathy (PDR).
Purpose of the Study:
- To compare the efficacy and safety of multi-spot versus single-spot scanning panretinal laser photocoagulation for NPDR.
- Evaluate treatment outcomes including visual acuity, macular thickness, and adverse reactions.
Main Methods:
- A randomized study included 49 NPDR patients (86 eyes), allocated to single-spot or multi-spot laser treatment groups.
- Outcomes assessed over 12 months included best-corrected visual acuity (BCVA), central macular thickness (CMT), and mean threshold sensitivity.
- Adverse reactions were systematically recorded.
Main Results:
- Multi-spot scanning used lower energy density, though overall energy levels were comparable to single-spot.
- Significant short-term improvements in BCVA and CMT were observed in the multi-spot group at one month.
- The incidence of adverse reactions was similar between the two treatment groups.
Conclusions:
- Multi-spot scanning panretinal photocoagulation demonstrates superior short-term efficacy in improving BCVA and CMT for NPDR patients.
- This method shows potential for reduced laser-induced damage compared to single-spot treatment.
- Both modalities are comparable in terms of energy intensity and safety.
