Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nile Blue Microsolvation Reveals Ion-Specific Lipid Binding.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Nevus lipomatosus cutaneous superficialis presenting as a coalescent gluteal plaque.

BMJ case reports·2026
Same author

Cutaneous infections and infestations.

Clinical and experimental dermatology·2026
Same author

Nature's Bandage: A Memorable Rescue of Severe Pemphigus Vulgaris in a Resource-Limited Setting.

Clinical and experimental dermatology·2026
Same author

Recurrent penile ulcer in an HIV-positive young man: An atypical presentation of secondary syphilis.

JAAD case reports·2026
Same author

Highlighting a histopathological dilemma: atypical dermatofibrosarcoma protuberans diagnosed with multimodal dermoscopy.

Skin health and disease·2026

Related Experiment Video

Updated: Jul 8, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.7K

Relapsed Gray Zone Lymphoma: A Rare Clinical Challenge.

Pratyaksh Chhabra1, Prerna Sahu1, Ishaan M Deshmukh1

  • 1Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Cureus
|August 28, 2024
PubMed
Summary

This case report details a rare instance of classical Hodgkin's lymphoma (HL) transitioning into relapsed or refractory gray zone lymphoma (GZL) in a young male. The patient experienced multiple relapses despite intensive treatments, including stem cell transplant.

Keywords:
adjuvant radiation therapychemotherapy-related toxicitydiffuse large b lymphomagray zone lymphomahodgkin lymphoma

More Related Videos

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

26.6K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K

Related Experiment Videos

Last Updated: Jul 8, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.7K
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

26.6K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Gray zone lymphoma (GZL) is a rare hematological malignancy with overlapping features of classical Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma.
  • Distinguishing GZL from HL can be challenging, particularly in cases with late-stage or atypical presentations.

Observation:

  • A 22-year-old male initially presented with classical Hodgkin's lymphoma.
  • The lymphoma transformed into relapsed or refractory gray zone lymphoma, exhibiting characteristics of both HL and diffuse large B-cell lymphoma.
  • The patient experienced two disease relapses, persisting even after undergoing peripheral blood stem cell transplantation.

Findings:

  • Initial biopsies suggested classical HL, but later biopsies during disease progression indicated GZL.
  • The case highlights the diagnostic complexity and aggressive nature of GZL, especially in its transformed state.
  • Despite a multi-modal treatment approach including chemotherapy, radiation therapy, and immunotherapy, the disease proved refractory.

Implications:

  • This case underscores the importance of thorough pathological evaluation and re-biopsy in managing challenging lymphoma cases.
  • Understanding the transition from HL to GZL may inform future diagnostic criteria and therapeutic strategies for these rare lymphomas.
  • Further research into the molecular mechanisms driving this transformation is warranted to improve patient outcomes.