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Grating Bio-Microelectromechanical Platform Architecture for Multiple Biomarker Detection.

Fahimeh Marvi^1,2, Kian Jafari^3,4, Mohamad Sawan^1,2

¹CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, China.

|August 28, 2024

Summary

This study introduces a label-free biosensor using a tunable microelectromechanical systems (MEMS) metamaterial. The device detects multiple biomarkers with high sensitivity in fluidic environments, advancing lab-on-chip technology.

Keywords:

BioMEMS sensing biological events biomarkers metamaterial structure optical measurements

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Area of Science:

• Nanotechnology and Materials Science
• Biosensing and Medical Diagnostics

Background:

• Existing biosensors often require labels, complicating detection.
• Microelectromechanical systems (MEMS) offer miniaturization and sensitivity for biosensing applications.
• Metamaterials provide unique optical properties exploitable for sensitive detection.

Purpose of the Study:

• To propose and analyze a novel label-free biosensor.
• To leverage a tunable MEMS metamaterial structure for enhanced biomolecule detection.
• To demonstrate the capability for multi-biomarker identification in fluidic environments.

Main Methods:

• Design of a one-dimensional array of metamaterial gratings with movable and fixed fingers.
• Utilization of surface stress effects to drive MEMS movement and alter grating patterns.
• Optical analysis of resonance wavelength shifts upon biomolecular binding.

Main Results:

• Achieved mechanical sensitivity of 11.55 μm/Nm⁻¹ and optical sensitivity of 8.08 μm/Nm⁻¹.
• Demonstrated a high quality factor (Q) of 102.7.
• Validated the potential for detecting multiple disease biomarkers at low concentrations with precision.

Conclusions:

• The proposed MEMS metamaterial biosensor offers a label-free and highly sensitive detection platform.
• The device's design supports multi-biomarker detection, crucial for complex diagnostics.
• This technology presents a promising bio-platform for integrated lab-on-chip systems.