Cuttlefish-Bone-Derived Biomaterials in Regenerative Medicine, Dentistry, and Tissue Engineering: A Systematic Review

Area of Science:

• Biomaterials Science
• Marine Biotechnology
• Regenerative Medicine

Background:

• Marine ecosystems offer vast biodiversity and potential for novel biomaterials.
• Cuttlefish bone (CB) is an emerging eco-friendly biomaterial derived from marine resources.

Purpose of the Study:

• To conduct a comprehensive review of biomedical applications of cuttlefish bone-derived materials.
• To evaluate both in vivo and in vitro studies on CB for diverse medical uses.

Main Methods:

• A systematic literature search identified 51 relevant studies from 2408 initial records.
• Included studies comprised in vivo animal models and in vitro investigations.

Main Results:

• In vivo applications include bone repair, wound healing, and muscle regeneration.
• In vitro studies focused on hydroxyapatite (HAp) synthesis, scaffold development, dental material improvement, and antimicrobial properties.
• Methodological quality varied, highlighting the need for standardized reporting and robust study designs.

Conclusions:

• This review provides a comprehensive overview of CB's biomedical potential, addressing a gap in current literature.
• CB-derived materials offer sustainable and effective solutions for regenerative medicine and dentistry.
• Findings offer insights for researchers, clinicians, and policymakers in biomaterials development.