Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The vascular endothelial cell antigen system.

J Cerilli, L Brasile, T Galouzis

    Transplantation
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Investigating strategies for control of Candidozyma auris biofilms on surfaces.

    The Journal of hospital infection·2026
    Same author

    Search for Light Dark Matter with NEWS-G at the Laboratoire Souterrain de Modane Using a Methane Target.

    Physical review letters·2025
    Same author

    Risks of epilepsy.

    Journal of neurology·2024
    Same author

    Assessing the stability and sporicidal efficacy of oxidizing disinfectants.

    The Journal of hospital infection·2024
    Same author

    Do in vitro pharmacological challenge responses differ between muscle specimens from malignant hyperthermia probands and their susceptible relatives?

    British journal of anaesthesia·2024
    Same author

    A global dataset of publicly available dengue case count data.

    Scientific data·2024
    Same journal

    Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

    Transplantation·2026
    Same journal

    Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

    Transplantation·2026
    Same journal

    Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

    Transplantation·2026
    Same journal

    People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

    Transplantation·2026
    Same journal

    IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

    Transplantation·2026
    Same journal

    Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

    Transplantation·2026
    See all related articles

    Vascular endothelial cell (VEC) antigens are immunogenic and can cause graft rejection, even in HLA-identical transplants. A positive monocyte crossmatch, indicating sensitization to VEC/monocyte antigens, is a contraindication for transplantation.

    Area of Science:

    • Immunology
    • Transplantation Science
    • Vascular Biology

    Background:

    • Vascular endothelial cells (VEC) express unique immunogenic antigens.
    • Peripheral blood monocytes share these VEC antigens, enabling prospective testing.
    • Preformed antibodies against VEC/monocyte antigens can lead to graft rejection.

    Purpose of the Study:

    • To investigate the immunogenicity of the VEC/monocyte antigen system.
    • To assess the impact of VEC/monocyte antibodies on graft survival.
    • To determine the clinical significance of monocyte crossmatch positivity.

    Main Methods:

    • Prospective monocyte crossmatch testing in 153 patients.
    • Evaluation of antibody reactivity against VEC and monocyte antigens.

    Related Experiment Videos

  • Analysis of graft rejection in relation to crossmatch results.

    • Main Results:

    • Approximately 7% of prospective monocyte crossmatches were positive when traditional crossmatches were negative.
    • Sensitization to VEC/monocyte antigens may explain up to 70% of early graft loss in living-related donors.
    • Antibody against donor monocytes exclusively was benign, unlike reactivity to VEC/monocyte antigens.

    Conclusions:

    • The VEC/monocyte antigen system is a significant immunogen in both HLA-identical and non-HLA-identical transplant combinations.
    • Positive monocyte crossmatch, indicating sensitization to VEC/monocyte antigens, is a contraindication to transplantation.
    • Genetic linkage between VEC/monocyte antigens and the major histocompatibility complex is suggested.