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Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through Its Interaction with Teneurin-4

Yuji Kurihara1,2, Yuki Kawaguchi1,3, Yuki Ohta4

  • 1Molecular Medical Bioscience Laboratory, Department of Medical Life Science, Yokohama City University Graduate School of Medical Life Science, Yokohama 230-0045, Japan.

Cells
|August 28, 2024
PubMed
Summary

Lateral olfactory tract usher substance (LOTUS) promotes neurite outgrowth by interacting with Teneurin-4 (Ten-4). This interaction is independent of Nogo receptor-1 (NgR1) and suggests a new mechanism for neuronal development and CNS repair.

Keywords:
Teneurin-4lateral olfactory tract usher substanceneurite outgrowth

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