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Plasmapheresis in hyperviscosity syndrome.

C Avnstorp, H Nielsen, O Drachmann

    Acta Medica Scandinavica
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Waldenström's macroglobulinaemia can cause circulatory issues due to high plasma viscosity. Plasmapheresis effectively reduced viscosity and symptoms, with a simple double-double pack system offering an alternative for acute hyperviscosity syndrome.

    Area of Science:

    • Hematology
    • Medical Technology

    Background:

    • Waldenström's macroglobulinaemia is a rare B-cell lymphoproliferative disorder.
    • Increased plasma viscosity is a known complication, leading to circulatory issues.

    Observation:

    • Three patients with Waldenström's macroglobulinaemia presented with circulatory complications attributed to plasma hyperviscosity (relative viscosity > 4).

    Findings:

    • Plasmapheresis, using a Haemonetics 30 S cell separator, plasma filtration (CPS 10 TM filter), or a double-double pack Fenwal system, effectively reduced plasma viscosity.
    • All patients experienced abolition of clinical symptoms following plasmapheresis.

    Implications:

    • Plasmapheresis is a viable treatment for hyperviscosity syndrome in Waldenström's macroglobulinaemia.

    Related Experiment Videos

  • The double-double pack system provides a less complex alternative for managing acute hyperviscosity, complementing advanced apheresis techniques.