Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

347
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
347
Tumor Immunotherapy01:27

Tumor Immunotherapy

493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Transmission-Loss Optical Waveguide Devices of Polyimides with Trifluoromethoxy-Enhanced Ultrahigh Refractive Index for Short-Distance Optical Communication.

ACS applied materials & interfaces·2026
Same author

Chemotherapy plus camrelizumab for fertility preservation (NACI-F) in FIGO stage IB1 cervical cancer: a multicenter, single-arm, phase 2 trial.

Journal of gynecologic oncology·2026
Same author

LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce.

Plant biotechnology journal·2026
Same author

Construct Optimization Enables Oncolytic Virus-Mediated Functional Membrane Localization of Calreticulin and Macrophage Reprogramming.

Human gene therapy·2026
Same author

Resveratrol targeting Smad4 via a concentration-dependent biphasic effect regulates stem cells-mediated regeneration.

Experimental and molecular pathology·2026
Same author

Genome-wide association study in a lettuce core collection from 811 accessions reveals genetic loci for anthocyanin accumulation and cultivar development.

Horticulture research·2026

Related Experiment Video

Updated: Jun 15, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

9.4K

Viral vector-based therapeutic HPV vaccines.

Teng Ji1,2, Yuchuan Liu3, Yutong Li3

  • 1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical and Experimental Medicine
|August 28, 2024
PubMed
Summary

Replication-defective viral vector vaccines offer potent immune responses for Human papillomavirus (HPV) infections. This review details therapeutic HPV viral vector vaccines, covering efficacy, and clinical trial progress.

Keywords:
Viral vectors; Human papillomavirus; Therapeutic vaccine; HPV-related malignancies

More Related Videos

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

21.9K
Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
12:21

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

13.2K

Related Experiment Videos

Last Updated: Jun 15, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

9.4K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

21.9K
Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
12:21

Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing

Published on: January 7, 2019

13.2K

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Human papillomavirus (HPV) is linked to numerous cancers, particularly HPV16-associated malignancies.
  • Therapeutic HPV vaccines using viral vectors are emerging for treating HPV-induced tumors and premalignant lesions.
  • Conventional subunit vaccines have limitations compared to viral vector approaches.

Purpose of the Study:

  • To review the current landscape of therapeutic HPV viral vector vaccines.
  • To summarize HPV infection, antigen selection, and vector technologies.
  • To discuss preclinical models, clinical trial progress, and efficacy of HPV vaccines.

Main Methods:

  • Review of preclinical models for assessing vaccine efficacy.
  • Analysis of current research on therapeutic HPV viral vector vaccines.
  • Summary of clinical trial data, including indications and combination therapies.

Main Results:

  • Viral vector vaccines induce strong antibody and cellular immune responses without adjuvants.
  • Numerous therapeutic HPV vaccine candidates are in development pipelines.
  • Preclinical models provide insights into vaccine efficacy, with ongoing clinical trials showing promise.

Conclusions:

  • Therapeutic HPV viral vector vaccines represent a promising strategy against HPV-related cancers.
  • Further research is needed for optimal antigen selection and method optimization.
  • This review provides a comprehensive overview of the field, highlighting progress and future directions.