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Summary

This summary is machine-generated.

This study introduces a novel CMOS biosensor array for rapid, label-free disease detection using electrochemical impedance spectroscopy (EIS). The high-density sensor achieves high sensitivity and scalability for point-of-care applications.

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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Published on: September 19, 2017

Area of Science:

Biomedical Engineering
Electrical Engineering
Sensor Technology

Background:

Point-of-care diagnostics require sensitive, label-free detection methods.
Electrochemical impedance spectroscopy (EIS) offers high sensitivity for disease detection.
Existing CMOS biosensor arrays face challenges in density, scalability, and readout efficiency.

Purpose of the Study:

To develop a high-density 16 × 20 CMOS biosensor array for label-free disease detection.
To implement a scalable, predominantly digital readout circuitry with in-pixel digitization.
To achieve state-of-the-art performance in phase-only EIS measurements for point-of-care applications.

Main Methods:

Designed a 16 × 20 CMOS biosensor array utilizing polar-mode, phase-only EIS measurements (5 kHz - 1 MHz).
Integrated a load-compensated transimpedance amplifier and predominantly digital readout circuitry within a 140 × 140 µm² pixel.
Employed in-pixel digitization and accumulation to enhance signal-to-noise ratio (SNR).

Main Results:

Achieved an rms phase error of 0.035% at 100 kHz using a duty-cycle insensitive phase detector.
Demonstrated a 10 dB SNR increase for every 10× readout time increase due to in-pixel accumulation.
Realized one of the smallest per-pixel areas with integrated quantization.

Conclusions:

The developed CMOS biosensor array offers a highly sensitive and scalable platform for rapid disease detection.
The design enables efficient label-free diagnostics at the point-of-care.
This technology advances integrated biosensing with improved SNR and reduced pixel area.