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Updated: Jun 15, 2025

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
Published on: January 15, 2018
Waste-Derived Copper Flakes for Solvent-Free Reductive Acetamidation of Nitroarenes
Nicky Kumar Lamba1, Pawan Choudhary1, Twinkle1
1Department of Chemistry, Malaviya National Institute of Technology Jaipur, J.L.N. Marg, Jaipur-302017, India.
Abstract:
Herein, waste-derived copper (Cu) flakes have been used as heterogeneous catalysts for the solvent-free and one-pot reductive acetamidation of nitroarenes. Metallic copper flakes (f-ZCu) were isolated from waste copper Cu scrap/flakes/turnings generated after the grinding and cutting (from the Cu industries). f-ZCu is being used to synthesize acetanilide with a considerable yield (∼82%) in one-step and solvent-free conditions within a reaction time of 6 h. Moreover, the same procedure is also being utilized for producing various substrates (9), including the gram-scale synthesis of the well-known important antipyretic drug, i.e., paracetamol. The plausible mechanism for the reaction was also proposed based on the spectroscopic analyses of spent f-ZCu.
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