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Updated: Jun 15, 2025

Reverse Total Shoulder Arthroplasty
Published on: July 5, 2011
Surgeon Prescribing Patterns And Perioperative Risk Factors Associated With Prolonged Opioid Use After Total Shoulder
Joshua D Pezzulo1, Dominic M Farronato, Robert Juniewicz
1From the Thomas Jefferson University School of Medicine, Philadelphia, PA (Pezzulo, Farronato, and Juniewicz), and The Rothman Institute at Thomas Jefferson University, Philadelphia, PA (Kane, Kellish, and Davis).
Nearly 22% of patients undergoing total shoulder arthroplasty (TSA) experienced prolonged opioid use. Preoperative opioid exposure, benzodiazepine use, and postoperative prescribing patterns were key risk factors identified for prolonged opioid utilization after TSA.
Area of Science:
- Orthopaedic Surgery
- Pain Management
- Public Health
Background:
- The opioid epidemic presents significant economic and mortality challenges in the US.
- Opioids are commonly used for pain management after total shoulder arthroplasty (TSA).
- Understanding prolonged opioid use after TSA is crucial for mitigating adverse outcomes.
Purpose of the Study:
- To investigate the incidence of prolonged opioid use after primary TSA.
- To identify independent risk factors associated with prolonged opioid utilization in TSA patients.
Main Methods:
- Retrospective review of 4,488 primary TSA cases from 2014-2022.
- Stratification based on preoperative and postoperative opioid use.
- Multivariate analysis to determine risk factors for prolonged opioid use (defined as >30 days post-op).
Main Results:
- 22% of patients developed prolonged opioid use post-TSA.
- Preoperative opioid exposure (OR 6.41) was the strongest risk factor.
- Other significant factors included younger age, female sex, non-Caucasian race, reverse TSA, urban residence, and benzodiazepine use.
Conclusions:
- Preoperative opioid exposure is a primary driver of prolonged use after TSA.
- Postoperative prescribing and benzodiazepine use also contribute significantly.
- Surgeons must optimize opioid management strategies to minimize risks associated with prolonged use.
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