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Updated: Jun 14, 2025
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora
Yi Ren1,2,3,4, Peng Huang1,2, Lu Zhang1,2
1Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Biomedicines
|August 29, 2024
Summary
The gut microbiome influences obesity through metabolites that affect energy and inflammation. Epigenetic changes, like DNA methylation, link gut microbes to obesity development and progression.
Area of Science:
- Metabolic disorders
- Microbiome research
- Epigenetics
Background:
- Obesity is a complex metabolic disorder influenced by genetics, environment, and diet.
- Intestinal microbes and metabolites impact energy metabolism, inflammation, and hormone secretion, contributing to obesity.
- Epigenetics, particularly DNA methylation, offers insights into how environmental factors influence obesity pathogenesis.
Purpose of the Study:
- To review the role of intestinal microbiota in obesity.
- To examine the involvement of DNA methylation in obesity.
- To explore the interaction between gut microbiota and DNA methylation in obesity.
Main Methods:
- Literature review of recent advancements.
- Analysis of studies on intestinal microbiota and obesity.
- Examination of research on DNA methylation and metabolic diseases.
Main Results:
- Intestinal microbiota and metabolites are key players in obesity development.
- DNA methylation is implicated in the pathogenesis of metabolic diseases, including obesity.
- Gut microbiota and metabolites can induce or regulate host epigenetic modifications, linking microbial activity to host gene expression.
Conclusions:
- The interplay between intestinal microbiota and DNA methylation is crucial in obesity.
- Understanding these interactions provides new perspectives for obesity prevention and treatment.
- Further research into microbiota-host epigenetics can elucidate obesity pathogenesis.
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