Current Non-Metal Nanoparticle-Based Therapeutic Approaches for Glioblastoma Treatment

Area of Science:

• Nanomedicine
• Oncology
• Biotechnology

Background:

• Glioblastoma multiforme (GBM) is a challenging primary brain tumor to treat.
• Nanotechnology offers novel therapeutic strategies for GBM.
• Nanoparticles (NPs) can overcome limitations of conventional GBM therapies.

Purpose of the Study:

• To review the potential of non-metal nanoparticles for glioblastoma multiforme (GBM) treatment.
• To highlight the advantages of NPs in drug delivery and targeting for GBM.
• To discuss the theranostic applications of NPs in malignant brain tumor therapy.

Main Methods:

• Review of current literature on non-metal nanoparticles for GBM treatment.
• Classification of NPs based on their core composition (metal vs. non-metal).
• Analysis of NP properties such as stability, biocompatibility, toxicity, and tumor accumulation.

Main Results:

• Non-metal NPs (e.g., exosomes, liposomes, polymeric NPs) demonstrate significant potential for GBM therapy.
• NPs improve drug stability, enhance blood-brain barrier penetration, and enable precise tumor targeting.
• Functionalization of NPs facilitates improved cargo delivery to GBM cells.
• NPs possess theranostic properties for imaging and photothermal therapy.

Conclusions:

• Non-metal nanoparticles represent a promising therapeutic approach for aggressive GBM tumors.
• Their inherent properties offer advantages over traditional treatment methods.
• Further development of non-metal NPs could significantly improve GBM treatment outcomes.