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  1. Home
  3. Serum Calcium Level At Diagnosis Can Predict Lethal Prostate Cancer Relapse.
  1. Home
  3. Serum Calcium Level At Diagnosis Can Predict Lethal Prostate Cancer Relapse.

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Serum Calcium Level at Diagnosis Can Predict Lethal Prostate Cancer Relapse.

Zsolt Fekete1,2, Patricia Ignat1,2, Henrietta Jakab1

  • 1Department of Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.

Journal of Clinical Medicine
|August 29, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

High normal blood calcium levels may predict fatal prostate cancer outcomes. This finding suggests calcium could be a new prognostic marker for prostate cancer patients receiving curative treatment.

Keywords:
early interventionfollow-upmetastasespredictive factorsprognostic factorsprostate cancerserum calciumtumor markers

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Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Prostate cancer prognosis relies on established factors like T stage, N stage, histology, grade group, and initial PSA.
  • Emerging research suggests a link between high-normal blood calcium levels and increased risk of fatal prostate cancer.
  • Limited data exists on the prognostic significance of calcium levels at diagnosis for prostate cancer.

Purpose of the Study:

  • To investigate the prognostic value of upper-normal range calcium levels in curatively treated prostate cancer patients.
  • To determine if calcium levels can predict disease-free survival in this cohort.

Main Methods:

  • Retrospective analysis of 84 prostate cancer patients undergoing curative-intent radiotherapy (external beam +/- brachytherapy).
  • Evaluation of prognostic factors impacting disease-free survival.
  • Analysis included calcium levels and initial PSA levels.

    • Main Results:

    • Calcium levels at diagnosis were found to be a significant predictor of disease-free survival.
    • Initial PSA levels did not demonstrate prognostic significance, potentially due to benign prostatic hyperplasia interference.
    • High-normal calcium levels may indicate a poorer prognosis.

    Conclusions:

    • Calcium levels at diagnosis may possess prognostic value in curatively treated prostate cancer.
    • Findings suggest calcium could be integrated into future prostate cancer predictive and prognostic models.
    • Further validation studies are recommended to confirm these results.