Valpalf^®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity

Area of Science:

• Biochemistry
• Immunology
• Nutraceutical Science

Background:

• Bovine lactoferrin (bLf) is an iron-binding glycoprotein with innate immunity functions.
• bLf exhibits anti-inflammatory and antioxidant properties linked to iron chelation and nuclear entry.
• High tolerance and pleiotropic functions make bLf a promising nutraceutical.

Purpose of the Study:

• To evaluate Valpalf®, a new formulation of bLf with sodium citrate and bicarbonate.
• To compare the bioactivity of Valpalf® against native bLf.
• To assess Valpalf®'s efficacy in cellular models and a clinical study for anemia of inflammation.

Main Methods:

• In vitro assessment of iron-binding capacity, tryptic digestion resistance, and nuclear accumulation.
• Evaluation of IL-6 reduction in lipopolysaccharide-stimulated macrophages.
• Modulation of antioxidant enzymes (SOD1, SOD2) in stimulated monocytes.
• Retrospective clinical study on anemia of inflammation in hereditary thrombophilic women.

Main Results:

• Valpalf® demonstrated superior iron-binding, digestion resistance, and nuclear accumulation compared to native bLf.
• Valpalf® significantly reduced IL-6 levels and modulated antioxidant enzyme expression.
• The formulation improved hematological parameters and reduced IL-6 in a clinical setting more effectively than bLf alone.

Conclusions:

• Valpalf® exhibits enhanced bioactivity due to its formulation.
• The formulation shows potential as an effective nutraceutical for inflammatory conditions and anemia.
• Valpalf® represents a superior alternative to native bLf for therapeutic applications.