TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia

Area of Science:

• Genetics
• Immunology
• Pulmonology

Background:

• Primary Ciliary Dyskinesia (PCD) is a rare inherited disorder affecting respiratory cilia, leading to recurrent infections.
• Chronic respiratory conditions are potential risk factors for SARS-CoV-2 acquisition.

Purpose of the Study:

• To investigate if individuals with PCD have increased susceptibility to SARS-CoV-2 infection.
• To determine if TAS2R38 bitter taste receptor gene polymorphisms correlate with SARS-CoV-2 infection prevalence and symptom severity in PCD patients.

Main Methods:

• A cohort of 40 adult PCD patients completed questionnaires regarding SARS-CoV-2 infection, symptoms, and vaccination status.
• COVID-19 positive patients also completed SNOT-22 and ARTIQ questionnaires.
• Genotyping for TAS2R38 polymorphisms was performed.

Main Results:

• 30% of PCD patients reported a COVID-19 diagnosis, mostly with mild symptoms.
• A statistically significant difference in Body Mass Index (BMI) was observed, higher in the COVID-19 positive group (p=0.03).
• No protective role of the PAV allele of TAS2R38 against SARS-CoV-2 infection was found.

Conclusions:

• PCD patients may not be at increased risk for severe COVID-19.
• TAS2R38 bitter taste receptor genotype does not appear to influence SARS-CoV-2 infection in individuals with PCD.