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Related Concept Videos

Obesity01:24

Obesity

416
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
159

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Related Experiment Video

Updated: Jun 14, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

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Obesity-Associated Colorectal Cancer.

Lucia Gonzalez-Gutierrez1, Omar Motiño1, Daniel Barriuso1

  • 1Unidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.

International Journal of Molecular Sciences
|August 29, 2024
PubMed
Summary

Obesity significantly increases colorectal cancer (CRC) risk and progression by promoting inflammation and molecular changes. New therapeutic targets are needed, and obesity reversal may enhance CRC treatments.

Keywords:
colorectal cancerepidemiologymolecular factorsobesityrisk factorstargetstreatments

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Area of Science:

  • Oncology
  • Metabolic Syndrome

Background:

  • Colorectal cancer (CRC) impacts millions globally, with obesity as a primary risk factor.
  • Obesity drives chronic inflammation and molecular alterations, accelerating tumor progression in CRC.
  • Current CRC treatments are not tailored for obesity-associated cases, highlighting a therapeutic gap.

Purpose of the Study:

  • To review the epidemiology, risk factors, and molecular mechanisms of obesity-associated CRC.
  • To summarize current treatment strategies for CRC in obese individuals.
  • To identify potential novel therapeutic targets for obesity-related CRC.

Main Methods:

  • Literature review of studies on obesity and colorectal cancer.
  • Analysis of molecular pathways linking obesity to cancer progression.
  • Synthesis of current treatment approaches and emerging therapeutic strategies.

Main Results:

  • Obesity is linked to increased CRC incidence and progression via inflammation and specific molecular factors.
  • Obesity-associated CRC shares characteristics like genome instability and altered microbial environments.
  • Existing CRC treatments lack specific adaptations for obese patients.

Conclusions:

  • Obesity is a critical factor in CRC development and progression.
  • Novel therapeutic targets focusing on obesity-related pathways are essential.
  • Reversing obesity should be explored as an adjunct strategy to improve CRC treatment outcomes.