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Updated: Jun 14, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
229
Obesity-Associated Colorectal Cancer.
Lucia Gonzalez-Gutierrez1, Omar Motiño1, Daniel Barriuso1
1Unidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, 47003 Valladolid, Spain.
International Journal of Molecular Sciences
|August 29, 2024
Summary
Obesity significantly increases colorectal cancer (CRC) risk and progression by promoting inflammation and molecular changes. New therapeutic targets are needed, and obesity reversal may enhance CRC treatments.
Area of Science:
- Oncology
- Metabolic Syndrome
Background:
- Colorectal cancer (CRC) impacts millions globally, with obesity as a primary risk factor.
- Obesity drives chronic inflammation and molecular alterations, accelerating tumor progression in CRC.
- Current CRC treatments are not tailored for obesity-associated cases, highlighting a therapeutic gap.
Purpose of the Study:
- To review the epidemiology, risk factors, and molecular mechanisms of obesity-associated CRC.
- To summarize current treatment strategies for CRC in obese individuals.
- To identify potential novel therapeutic targets for obesity-related CRC.
Main Methods:
- Literature review of studies on obesity and colorectal cancer.
- Analysis of molecular pathways linking obesity to cancer progression.
- Synthesis of current treatment approaches and emerging therapeutic strategies.
Main Results:
- Obesity is linked to increased CRC incidence and progression via inflammation and specific molecular factors.
- Obesity-associated CRC shares characteristics like genome instability and altered microbial environments.
- Existing CRC treatments lack specific adaptations for obese patients.
Conclusions:
- Obesity is a critical factor in CRC development and progression.
- Novel therapeutic targets focusing on obesity-related pathways are essential.
- Reversing obesity should be explored as an adjunct strategy to improve CRC treatment outcomes.
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