Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progression

Area of Science:

• Molecular Biology
• Genetics
• Respiratory Medicine

Background:

• Chronic obstructive pulmonary disease (COPD) and lung cancer are major global health concerns with complex underlying mechanisms.
• Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in various biological processes and diseases.

Purpose of the Study:

• To review the multifaceted roles of lncRNAs in the pathogenesis of COPD and lung cancer.
• To explore the diagnostic, prognostic, and therapeutic implications of lncRNAs in these respiratory diseases.

Main Methods:

• Comprehensive literature review integrating diverse research perspectives.
• Analysis of lncRNA dysregulation in COPD and lung cancer pathogenesis.
• Examination of lncRNA-mediated immune responses in lung cancer.

Main Results:

• Specific lncRNAs (NEAT1, TUG1, MALAT1, HOTAIR, GAS5) are implicated in COPD pathogenesis and progression.
• LncRNAs modulate lung cancer progression, immune responses, and chemo-resistance.
• Dysregulated lncRNAs serve as potential diagnostic and prognostic biomarkers for both diseases.

Conclusions:

• LncRNAs hold significant potential for developing novel diagnostic and therapeutic strategies for COPD and lung cancer.
• Further research into lncRNA-based interventions could lead to personalized treatments and improved clinical outcomes.