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Outcomes in COVID-19 Patients with Acute Cholangitis: A Single-Center Retrospective Analysis

Deiana Vuletici1,2, Bogdan Miutescu1,2, Calin Burciu1,2,3

  • 1Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.

Medicina (Kaunas, Lithuania)
|August 29, 2024
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly increased hospitalization duration for acute cholangitis (AC) patients. COVID-19 also influenced AC

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Oncology

Background:

  • Acute cholangitis (AC) is a serious biliary tract infection.
  • The impact of coronavirus disease 2019 (COVID-19) on AC patient outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the effects of COVID-19 on AC patients.
  • To compare outcomes, complications, and hospital stays between AC patients with and without COVID-19.

Main Methods:

  • Retrospective observational cohort study of 241 AC patients (April 2020-February 2022).
  • Patients were divided into COVID-19 positive and negative groups.
  • Diagnosis of AC followed Tokyo Guidelines 2018 (TG18); bile cultures were performed.

Main Results:

  • The COVID-19 group was older (74.3 vs. 67.3 years) and presented more frequently with abdominal pain (90% vs. 70.6%).
  • Hospital stays were longer for COVID-19 patients (13.5 vs. 7.9 days).
  • Malignant causes of AC, particularly pancreatic cancer (30%), and *Pseudomonas* spp. prevalence (16.7% vs. 5.7%) were higher in the COVID-19 group.

Conclusions:

  • COVID-19 significantly prolonged hospitalization for AC patients.
  • COVID-19 infection is associated with distinct microbial profiles in AC, including increased *Pseudomonas* spp.
  • Higher incidence of malignant AC observed in COVID-19 patients warrants further research.

Keywords:
COVID-19acute cholangitisbiliary drainagemicroorganisms

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